Abstract Medication-related osteonecrosis of the jaw (MRONJ) is characterized by bone exposure for more than eight weeks in patients who have used or been treated with antiresorptive or antiangiogenic drugs, without a history of radiation therapy or metastatic diseases in the jaws. Obesity is associated with changes in periodontal tissues and oral microbiota that are linked to bone alterations. This study aimed to analyze the influence of obesity on the development of bisphosphonate-induced osteonecrosis. The experiment randomly and simply divided 24 male Wistar rats (Rattus norvegicus) into four groups: healthy, with osteonecrosis, obese, and obese with osteonecrosis (n=6 per group). Osteonecrosis was induced through weekly intraperitoneal injection for eight weeks at a dose of 250 µg/kg of zoledronic acid in a 4 mg/5 mL solution, combined with trauma (exodontia). Obesity was induced through a high glycaemic index diet. Each group was qualitatively and quantitatively evaluated regarding the development of models and pathological anatomy of the lesions. The results were expressed in mean percentage and standard deviation and statistically analyzed using one-way analysis of variance (ANOVA) followed by Tukey's post-hoc test, with a significance level of 5% (p<0.05) to establish differences found between the groups. Animals in the osteonecrosis group and the obese with osteonecrosis group presented larger necrosis areas (averages: 172.83±18,19 µm2 and 290.33±15,77 µm2, respectively) (p<0,0001). Bone sequestration, hepatic steatosis, and increased adipocyte size were observed in the obese group (average: 97.75±1.91 µm2) and in the obese with osteonecrosis group (average: 98.41±1.56 µm2), indicating greater tissue damage in these groups (p<0,0001). All parameters analyzed (through histological, morphometric, and murinometric analyses) increased for the obese and obese with osteonecrosis groups, suggesting a possible influence of obesity on the results. However, further studies are needed to confirm the role of obesity in the possible exacerbation of osteonecrosis and understand the underlying mechanisms.

Resumo Esta pesquisa intencionou compreender como, a partir dos relatos narrativos (auto)biográficos de três docentes negras do ensino superior público, implodem-se saberes e fazeres que decolonizam o conhecimento, a ciência e a sociedade no âmbito da UFMG. Tomou-se a experiência dessas sujeitas como analisadores das inúmeras contradições que se apresentam em uma universidade pública de histórico moderno/colonial. O que tem sido capaz de movimentar rupturas epistêmicas e políticas na reinvenção de um novo mundo que já se mostra possível apesar das armadilhas da colonialidade. Nessa direção, as estratégias de combate à colonização do ser, do saber e da sociedade são um processo constante de mobilizações e alterações dessas experiências. É, apenas e unicamente, por meio dessa ferida aberta, que essas intelectuais inventam outros horizontes na produção do conhecimento, da ciência e da própria sociedade em sua versão mais justa rumo à experiência-ciência feminista, antirracista e decolonial. autobiográficos auto biográficos público implodemse implodem conhecimento UFMG Tomouse Tomou modernocolonial moderno colonial moderno/colonial colonialidade direção ser experiências É unicamente aberta experiênciaciência feminista decolonial

Resumen Esta investigación pretendió comprender cómo, a partir de los relatos (auto)biográficos de tres profesores negros de educación superior pública, se implosionan saberes y acciones que descolonizan el saber, la ciencia y la sociedad en el ámbito de la UFMG. Se tomó la experiencia de estos sujetos como analizadores de las innumerables contradicciones que se presentan en una universidad pública de historia moderna/colonial. Lo que ha podido mover rupturas epistémicas y políticas en la reinvención de un mundo nuevo que ya es posible a pesar de las trampas de la colonialidad. En esa dirección, las estrategias para combatir la colonización del ser, el saber y la sociedad son un proceso constante de movilización y alteración de estas experiencias. Es, única y exclusivamente, a través de esta herida abierta, que estos intelectuales inventan otros caminos en la producción del conocimiento, la ciencia y la sociedad misma en su versión más justa hacia la experiencia-ciencia feminista, antirracista y decolonial. cómo autobiográficos auto biográficos UFMG modernacolonial moderna colonial moderna/colonial colonialidad dirección ser experiencias Es exclusivamente abierta conocimiento experienciaciencia feminista decolonial

Abstract This research intended to understand how knowings and doings that decolonize knowledge, science and society in the scope of the UFMG are imploded, from the (auto)biographical narrative reports of three black teachers of public higher education. The experience of these teachers was taken as analyzers of the innumerable contradictions that appear in a public university of modern/colonial history. This has been able to move epistemic and political ruptures in the reinvention of a new world that is already possible despite the traps of coloniality. In this direction, the strategies to combat the colonization of the being, of knowledge and of society are a constant process of mobilization and alteration of these experiences. Only and solely, it is through this open wound that these intellectuals invent other paths in the production of knowledge, science and society itself in its fairest version towards feminist, anti-racist and decolonial experience-science. imploded autobiographical auto biographical education moderncolonial modern colonial history coloniality direction being experiences solely feminist antiracist anti racist experiencescience. experiencescience science. experience-science

Aim: To describe the management of dental education in three dental schools during the COVID-19 crisis. Methods: Adopted strategies in the Federal University of Paraíba (UFPB), Brazil, University of Pittsburgh (UP), USA, and Griffith University (GU), Australia were detailed. Results: In the UFPB, all on-site teaching was suspended, and resources for distance learning set up as a supplementary semester to be available as face to face classes later. A protocol for clinical care followed safety measures recommended by Brazilian official health institutions. The adequacy of the physical structure, human resources, and personal protective equipment (PPE) acquisition for the return to clinical activities are currently under discussion. In the UP, learning activities were shifted to virtual teaching using lecture recordings and live sections. All elective patients care was postponed. Urgent dental cases were discussed via teledentistry. The physical layout of the dental clinics and pre-clinical laboratories were changed, allowing a safe distance between students. In the GU, all clinical and pre-clinical activities were cancelled, and theoretical activities were maintained online for all students. Several clinically based scenarios where created and delivered in the format of online problem-based learning. The reception area was redesigned, ensuring social distancing. Safety measures follow the Australia Dental Association. Conclusions: Dealing with dental education depends on the stage of the epidemic and the characteristics of each country.

Abstract Natural products have emerged as a rich source of bioactive compounds for adjunctive treatments of many infectious and inflammatory conditions, including periodontitis. Among the monoterpenes with significant biological properties, there is the perillyl alcohol (POH), which can be found in several essential oils and has shown immunomodulatory properties in recent studies, which may be interesting in the treatment of non-neoplastic inflammatory disorders. Objective To determine the antibacterial and immune modulatory activities of the POH. Methodology The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the POH for two significant Gram-negative periodontal pathogens were determined by macrodilution and subculture, respectively. Cell proliferation and cytotoxicity in RAW 264.7 macrophages were determined by Trypan Blue and mitochondrial enzymatic activity assay. The modulation of reactive oxygen species (ROS) was analyzed by flow cytometry and expression of TNF and arginase-1 by real-time PCR. Results The POH was effective against P. gingivalis (ATCC 33277) and F. nucleatum (ATCC 25586) with MIC= MBC=1600 μM. No cytotoxicity up to 100 µM was observed on macrophages. The cell proliferation was inhibited from 48 hours at 100 μM (p<0.05) and 250 μM (p<0.01). The POH increased ROS production at both 10 μM and 100 μM (p<0.05) in unstimulated cells. The PMA-induced ROS production was not affected by POH, whereas 100 μM significantly reduced lipopolysaccharide-induced (LPS-induced) ROS. The expression of TNF was not affected by POH in unstimulated cells or in cells polarized to M1 phenotype, whereas both concentrations of POH reduced (p<0.05) the expression of arginase-1 in M2-polarized macrophages. Conclusion The POH has antibacterial activity against periodontal pathogens and reduced proliferation of murine macrophages without significant cytotoxicity at concentrations up to 100 μM. In addition, the POH reduced the LPS-induced ROS and the expression of arginase-1 in M2-polarized macrophages.

Abstract We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i.p.) and vehicle (saline + Tween 80 at 0.2%, i.p.) 30 minutes prior to the beginning of the experiment. Injecting glutamate (25 μM), capsaicin (2.5 μg) and formalin (2%) into the right upper lip (perinasal) of the mouse induced nociception. Behavioral analysis of the animals considered the friction time (in seconds) of the mentioned region using hind or front paws by a researcher blinded to the treatment groups. The statistical analysis was performed blindly, considering α = 5%. The results showed that in the glutamate and capsaicin tests, concentrations of 25 mg/kg and 50 mg/kg presented antinociceptive activity (p < 0.005, power> 80%). In the formalin test, geraniol was able to reduce nociception at a concentration of 50 mg/kg (p < 0.005, power> 80%). In the molecular anchorage study, high values of binding between the evaluated substance and receptors of glutamate were observed (metabotropic glutamate receptor, -87.8501 Kcal/mol; N-methyl-D-aspartate, -86.4451 Kcal/mol; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid, -85.6755 Kcal/mol). Geraniol presented orofacial antinociceptive activity, probably by interacting with glutamate-related receptors.

Abstract Objective: To describe and compare how three dental schools from different countries (Australia, Brazil, and the USA) have managed experiences in dental education during the COVID-19 crisis. Material and Methods: It is a descriptive study reporting the experience that three distinct dental schools faced during the COVID-19 pandemic. They represent countries that adopted different measures to tackle the pandemic and were undergoing different stages of the disease. Results: After the WHO declared the COVID-19 pandemic, the Federal University of Paraíba suspended all on-site teaching, research, and service activities. For the return to teaching activities, the use of information and communications technology resources for distance learning was recommended. At the School of Dental Medicine (University of Pittsburgh), all research activities were suspended or, otherwise, could not be interrupted because of the employment of unique materials or supplies. When the pandemic started, Australia was one of the first countries to introduce strong regulations related to social distancing, travel restrictions, testing and tracking of infected patients. As such, the universities started to be closed from mid-March, cancelling all clinical and pre-clinical activities, maintaining online theoretical activities, such as seminars, lectures, and journal clubs. Conclusion: Numerous and critical difficulties have arisen as a result of the pandemic for individuals, communities and institutions that will have long-lasting effects. Our students face disruption to their education and career; our professional colleagues will be challenged rebuilding their practices, while staff at all Dental Schools are experiencing various hardships.

Abstract Objective: This study sought to identify the differences between the oral changes presented by patients with solid and hematologic tumors during chemotherapeutic treatment. Methodology: This is an observational, prospective and quantitative study using direct documentation by follow-up of 105 patients from 0 to 18 years using the modified Oral Assessment Guide (OAG). Of the 105 patients analyzed, 57 (54.3%) were boys with 7.3 years (±5.2) mean age. Hematologic neoplasms accounted for 51.4% of all cases. Results: Voice, lips, tongue, and saliva changes were not significantly different (p>0.05) between patients with solid or hematologic tumors and during the follow-up. From the 6th until the 10th week of chemotherapeutic treatment alterations in swallowing function, in the mucous membrane (buccal mucosa and palate), in the labial mucosa, and in the gingiva occurred and were distributed differently between the two tumors groups (p<0.05). The main alterations were observed in patients with hematologic tumors. Conclusion: It was concluded that the oral changes during the chemotherapeutic treatment occurred especially in swallowing function, in the mucous membrane, in the labial mucosa and in the gingiva, and these alterations were found mainly in patients with hematologic tumors.

Abstract Objective: To perform chemical analysis and to evaluate the anti-biofilm and hemolytic effect of the essential oil of Cymbopogon citratus. Material and Methods: Gaseous chromatography coupled to mass spectrometer was performed for chemical characterization of the essential oil. To verify the antimicrobial action, the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicidal Concentration (MFC) were determined. From MIC, MBC and MFC data, concentrations were established to verify the anti-biofilm effect and for the hemolysis test on human erythrocytes. A multispecies biofilm was developed in vitro and mouthwash applications were simulated to determine the inhibition of biofilm formation or its removal. Results were analyzed through ANOVA statistical test, complemented by the Tukey test, considering a significance level of 5% Results: The major component of the essential oil is citral. MIC verified for Streptococcus mutans was 1mg / mL, while for Candida albicans, it was 125 μg/mL, presenting microbicidal effect for both microorganisms tested. The essential oil was able to inhibit biofilm formation (p<0.001), presenting non-toxic hemolysis percentage in concentration below 500 μg/mL Conclusion: The essential oil of Cymbopogon citratus is antimicrobial, antibiofilm and non-toxic to human erythrocytes, representing a natural product with potential for use in Dentistry.

Abstract Objective: To identify the profiles of patients with special needs attended at a Center for Dental Specialties. Material and Methods: This was a cross-sectional and quantitative study using an inductive approach, and a comparative and statistical procedure for analysis of the patients with special needs. Information concerning socioeconomic, medical and dental conditions was collected. The data were analyzed using IBM SPSS, adopting a significance level of 5%. Results: It was observed that 58.6% of the users were males, single (54.7%), in the age group from 19 to 59 years (41.1%), being 97.4% without schooling. The most frequent clinical diagnoses were: deviations in intelligence (18.4%), behavioral deviations (18.4%) and physical defects (17.9%). We observed for oral health the presence of gingivitis (33.0%), and healthy gums (47.8%); the presence of caries (64.9%), with restored teeth (28.5%), and edentulism (12.3%). Dental intervention procedures were initiated with emphasis on: fluoride applications (39.7%) and subgingival scraping (34.9%). Topical fluoride applications (p=0.010) and prophylaxis (p=0.010) were realized in patients without autism. Also, prophylaxis (p=0.007) was more frequently performed and gingival alterations were more often verified (p=0.020) in patients without Down's syndrome. Conclusion: The users of the patients with special needs dental service can be generally described as male, single, aged between 19 and 54 years, with the special conditions of intelligence and behavioral deviation.

RESUMO Objetivo: verificar o perfil dos usuários com queixas fonoaudiológicas do serviço de atenção domiciliar do município de João Pessoa, Paraíba. Métodos: trata-se de um estudo transversal, descritivo, natureza quantitativa, mediante técnica de documentação indireta a partir da análise de documentos de fontes primárias, sendo caracterizado, portanto, como estudo documental. A pesquisa foi realizada junto ao serviço de atenção domiciliar (SAD) do município de João Pessoa/PB, que dispõe de informações dos usuários armazenadas em forma de prontuários. Todos os prontuários dos pacientes atendidos pelo SAD no período de junho de 2012 a junho de 2016 foram analisados, e após os critérios de elegibilidade, amostra ficou constituída por 114 prontuários. Os dados coletados foram inseridos em uma planilha do Microsoft Excel para realização de estatística descritiva no Software IBM SPSS (versão 21.0). Resultados: verificou-se que a maioria dos pacientes atendidos foi do sexo masculino (59,6%), idosos (62,3%) e diagnosticados com acidente vascular encefálico (57,9%). Além disso, apresentaram histórico de disfagia (76,3%), problemas de fala (58,8%), deglutição alterada (80,7%) e mastigação alterada (77,2%). A disfagia está frequentemente associada aos AVE’s apresentando predomínio de indivíduos do sexo masculino e idosos. Conclusão: concluiu-se que a alteração de dificuldade de deglutição, ou seja, a disfagia está frequentemente associada aos AVE’s apresentando o predomínio das variáveis sociodemográficas e clínicas de homens e idosos.

ABSTRACT Objective: to ascertain the profile of home care service (HCS) users with speech and language complaints in João Pessoa, Paraíba (PB). Methods: a descriptive and quantitative study using an indirect documentation technique based on an analysis of primary source documents, characterized as a documentary study, conducted at a HCS, in João Pessoa, PB, that stores user information in the form of medical records. All patient records included by the HCS from June 2012 to June 2016 were analyzed. After the eligibility criteria were applied, the sample consisted of 114 medical records. The collected data were entered into a Microsoft Excel spreadsheet to generate descriptive statistics using IBM SPSS (version 21.0). Results: most patients were males (59.6%), elderly (62.3%), had been diagnosed with a stroke (57.9%),had histories of dysphagia (76.3%), speech problems (58.8%), swallowing disorders (80.7%), and abnormal chewing (77.2%). Dysphagia is often associated with stroke, predominantly among males and the elderly. Conclusion difficulty in swallowing, or dysphagia, is often associated with stroke, predominantly in the presence of the sociodemographic and clinical variables associated with men and the elderly.

RESUMO Objetivo: objetivou-se avaliar a qualidade metodológica dos ensaios clínicos publicados em periódicos brasileiros. Métodos: trata-se de uma pesquisa bibliográfica sistemática. Participaram quatro pesquisadores independentes treinados que realizaram um levantamento dos últimos 10 anos em todos os periódicos nacionais da área da Fonoaudiologia, ativos ou inativos. Para tanto, foram selecionados todos os volumes desse período de tempo e cada pesquisador realizou análise individual a fim de identificar estudos que tinham o principal objeto de estudo enquadrado na Motricidade Orofacial. Foram utilizados os seguintes instrumentos Downs and Black Quality Checklist e escala de Jadad. Resultados: após a seleção e categorização dos estudos, a amostra final desta pesquisa foi composta por 6 artigos classificados como ensaios clínicos. Dentre as limitações metodológicas observadas destacam-se a ausência de plano amostral, randomização e cegamento. Identificou-se uma média de 16,3 pontos para o Downs and Black Quality Checklist e 2,3 para escala de Jadad. Conclusão: conclui-se que a literatura brasileira é escassa de ensaios clínicos controlados randomizados na área de motricidade orofacial, sugerindo ampliação e qualificação das investigações que adotam esse delineamento de pesquisa, promovendo, dessa forma, uma prática clínica baseada em evidência científica.

ABSTRACT Purpose: to evaluate the methodological quality of clinical trials published in Brazilian journals. Methods: four trained independent researchers conducted a systematic literature search of all Brazilian speech therapy-related journals over the last ten years, whether the journals were active or inactive. All journal volumes published during that period were selected, and each researcher conducted an individual analysis to identify articles that focused primarily on orofacial motricity. The tools used were the Downs and Black Quality Checklist and the Jadad scale. Results: after the studies were selected and categorized, the final sample comprised six articles, all of which were classified as clinical trials. The observed methodological limitations included a lack of sample planning, randomization and blinding. Mean scores of 16.3 points on the Downs and Black Quality Checklist and 2.3 on the Jadad scale were obtained. Conclusion: the randomized controlled trials in the area of orofacial motricity are scarce in Brazilian literature, suggesting that studies in this area adopting this research design should be expanded and their quality should be improved to promote clinical practice based on scientific evidence.

Abstract The effect of fluoride agents on the retention of orthodontic brackets to enamel under erosive challenge is little investigated. Objective: The aim of this study was to evaluate the effect of titanium tetrafluoride (TiF4) and sodium fluoride (NaF) agents on the shear bond strength of brackets to enamel and on the enamel microhardness around brackets under erosive challenge. Methods: Brackets were bonded to bovine incisors. Five groups were formed according to fluoride application (n=10): TiF4 varnish, TiF4 solution, NaF varnish, NaF solution and control (without application). The specimens were submitted to erosive challenge (90 s cola drink/2h artificial saliva, 4x per day for 7 days). Solutions were applied before each erosive cycle and varnishes were applied once. Vickers Microhardness (VHN) was obtained before and after all cycles of erosion and the percentage of microhardness loss was calculated. Shear bond strength, adhesive remnant index and polarized light microscopy were conducted after erosion. The data were analyzed by ANOVA, Tukey, Kruskal-Wallis and Mann-Whitney U tests (α=0.05). Results: The %VHN had no statistically significant differences among the experimental groups. However, considering the comparisons of all groups with the control group, TiF4 varnish showed the highest protection from enamel demineralization (effect size of 2.94, while the effect size for the other groups was >2.4). The TiF4 varnish group had significantly higher shear bond strength compared to other groups. There was no difference among groups for adhesive remnant index. Polarized light microscopy showed higher demineralization depth for the control group. Conclusions: Application of NaF and TiF4 agents during mild erosive challenge minimized the enamel mineral loss around brackets, however only the experimental TiF4 varnish was able to prevent the reduction of shear bond strength of brackets to enamel.

Resumo Introdução A incidência de câncer de lábio, cavidade bucal e orofaringe no Brasil é uma das maiores do mundo. Objetivo Este estudo teve como objetivo identificar preditores para o câncer bucal no Brasil entre 2010 e 2013. Método Mediante um estudo de série temporal em que foram avaliados 14.959 diagnósticos primários de câncer de cabeça e pescoço. As variáveis de interesse foram: gênero, idade, raça, nível de escolaridade, histórico familiar de câncer, consumo de álcool, tabagismo e diagnóstico anterior de câncer. A variável desfecho foi dividida em “câncer de boca” e “câncer de outras regiões de cabeça e pescoço”. Os dados foram analisados por regressão logística binária múltipla; α = 5%. Resultado O fator de proteção foi: ter aproximadamente 12 anos de escolaridade (OR = 0,85). Os fatores de risco foram: ser um ex-consumidor (OR = 1,19) ou consumidor (OR = 1,11) de álcool, tabagismo (OR = 1,35) e o diagnóstico prévio de câncer sem tratamento (OR = 1,21). Conclusão Concluiu-se que o câncer bucal possui os seguintes preditores em comparação com outros tipos de câncer de cabeça e pescoço durante o mesmo período: ter aproximadamente 12 anos de estudo (fator de proteção) e ser ex-consumidor ou consumidor de álcool, tabagismo e ter tido um diagnóstico prévio de câncer sem tratamento (fatores de risco).

Abstract Introduction The incidence of lip, oral cavity and oropharynx cancer in Brazil is one of the highest worldwide. Objective This study aimed to identify predictors for oral cancer in Brazil between 2010 and 2013. Method Through a time series study in which 14,959 primary head and neck cancer diagnoses were evaluated. The variables of interest were gender, age, race, education level, family history of cancer, alcohol consumption, smoking, and previous cancer diagnosis. The outcome variable was divided into “oral cancer” and “cancer of other head and neck regions.” The data were analysed by multiple binary logistic regression; α=5%. Result The protective factor was: approximately 12 years of education (OR = 0.85). The risk factors were: being an ex-consumer (OR=1.19) or consumer (OR=1.11) of alcohol, tobacco use (OR=1.35) and a prior diagnosis of cancer that went untreated (OR=1.21). Conclusion Was concluded that the oral cancer had the following predictors compared to other types of head and neck cancer during the same period: approximately 12 years of education (protective factor) and ex-consumer or consumer of alcohol, smoking and previous diagnosis of cancer that went untreated (risk factors).

Resumo Crianças em idade escolar apresentam, com frequência, alto risco para o desenvolvimento de doenças biofilme-dependentes, incluindo cárie e doenças periodontais. Este estudo investigou a eficácia clínica de um dentifrício contendo o extrato de Eugenia uniflora Linn. (pitanga) comparado a um dentifrício com triclosan no combate à gengivite em crianças de 10 a 12 anos. Foi avaliado o potencial antibacteriano in vitro do dentifrício sobre microorganismos da cavidade oral (S. mutans S. oralis and L. casei) e realizado um estudo clínico fase II incluindo 50 sujeitos, com sinais clínicos de gengivite, divididos aleatoriamente em dois grupos: Experimental - 25 sujeitos usaram o dentifrício contendo extrato de pitanga; e Controle - 25 sujeitos que usaram um dentifrício fluoretado contendo triclosan (Colgate Total 12(r)). Na baseline e após sete dias consecutivos de escovação, foi realizado o exame clínico para diagnóstico de gengivite (desfecho primário) e acúmulo de biofilme (desfecho secundário), utilizando o Índice de Sangramento Gengival (ISG) e Índice de Higiene Oral Simplificado (IHO-S). Os dados foram analisados utilizando o teste t pareado e não pareado (ISG) e teste de Wilcoxon e Mann-Whitney (IHO-S), com nível de significância de p≤0,05. Observou-se uma efetiva atividade antibacteriana do dentifrício experimental. No estudo clínico, observou-se redução de sangramento gengival em ambos os grupos experimental e controle (p<0,0001), não havendo diferença entre eles (p 0,178), embora com uma pequena magnitude de efeito. Apenas o grupo controle reduziu significantemente o acúmulo de biofilme (p=0,0039). Concluiu-se que o dentifrício experimental de E. uniflora mostrou-se eficaz na redução de gengivite em crianças de 10 a 12 anos. Assim, este dentifrício apresenta potencial para ser utilizado de forma eficaz e segura em odontologia preventiva.

Abstract School-age children are frequently at high risk for the onset of biofilm-dependent conditions, including dental caries and periodontal diseases. The objective of this study was to evaluate the clinical efficacy of a dentifrice containing Eugenia uniflora Linn. (Surinam cherry) extract versus a triclosan-based comparator in treating gingivitis in children aged 10-12 years. The in vitro antibacterial potential of the dentifrice was tested against oral pathogens (Streptococcus mutans, Streptococcus oralis and Lactobacillus casei). Then a phase-II clinical trial was conducted with 50 subjects aged 10-12 years, with clinical signs of gingivitis. The subjects were randomly assigned to the experimental group (n=25) and control group (n=25), in which participants used the experimental dentifrice and a triclosan-based fluoridated dentifrice (Colgate Total 12(r)), respectively. Clinical examinations assessed the presence of gingivitis (primary outcome) and biofilm accumulation (secondary outcome) using the Gingival-Bleeding Index (GBI) and Simplified Oral Hygiene Index (OHI-S), respectively, at baseline and after seven days of tooth brushing 3x/day. The data were analyzed using paired and unpaired t-test (GBI) and Wilcoxon and Mann-Whitney (OHI-S), with p≤0.05. The experimental dentifrice showed efficient antibacterial activity in vitro. In the clinical trial, a significant reduction in gingival bleeding was observed in both experimental and control groups (p<0.0001), with no statistical difference between them (p=0.178), although a small size effect was observed. Biofilm accumulation was only reduced in the control group (p=0.0039). In conclusion, E. uniflora dentifrice showed anti-gingivitis properties in children aged 10-12 years. Thus, it may be a potentially efficient and safe product to be used alternatively in preventive dental practice